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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRKCI
All Species:
16.06
Human Site:
S246
Identified Species:
25.24
UniProt:
P41743
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P41743
NP_002731.4
596
68262
S246
T
R
E
S
G
K
A
S
S
S
L
G
L
Q
D
Chimpanzee
Pan troglodytes
XP_001148501
597
67369
S249
G
M
D
G
I
K
I
S
Q
G
L
G
L
Q
D
Rhesus Macaque
Macaca mulatta
XP_001089400
597
68263
S247
T
R
E
S
G
K
A
S
S
S
L
G
L
Q
D
Dog
Lupus familis
XP_535855
696
78257
S346
T
R
E
S
G
K
A
S
S
S
L
G
L
Q
D
Cat
Felis silvestris
Mouse
Mus musculus
Q62074
595
68185
S245
T
R
E
S
G
K
A
S
S
S
L
G
L
Q
D
Rat
Rattus norvegicus
P09217
592
67715
D236
E
D
L
K
P
V
I
D
G
V
D
G
I
K
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506164
360
41199
V49
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
Chicken
Gallus gallus
XP_417561
606
69931
D250
E
D
I
K
P
V
I
D
G
M
D
G
I
K
I
Frog
Xenopus laevis
NP_001084068
588
67442
P238
S
R
E
S
G
K
S
P
S
S
L
G
L
Q
D
Zebra Danio
Brachydanio rerio
Q90XF2
588
67303
V238
S
R
E
S
G
K
A
V
S
S
L
G
L
I
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P13678
634
71138
G285
S
L
A
V
T
G
S
G
G
V
G
A
T
G
E
Honey Bee
Apis mellifera
XP_397273
590
68031
H233
I
E
E
H
S
R
N
H
N
S
N
D
M
Q
R
Nematode Worm
Caenorhab. elegans
Q19266
597
68017
M238
S
H
D
A
S
R
A
M
N
G
N
G
S
S
K
Sea Urchin
Strong. purpuratus
XP_780275
524
59689
I213
R
V
Y
A
M
K
V
I
K
K
E
L
V
T
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
P87253
1142
127954
P655
L
M
Y
S
Q
T
T
P
R
P
G
G
P
D
R
Conservation
Percent
Protein Identity:
100
66.6
96.8
84.3
N.A.
98.3
72.3
N.A.
59.9
71.4
89.7
88.7
N.A.
36.4
67.9
58.1
63.5
Protein Similarity:
100
78.5
97.4
84.9
N.A.
98.8
83.5
N.A.
60.4
83
94.4
92.9
N.A.
54
78.1
74.1
72.4
P-Site Identity:
100
46.6
100
100
N.A.
100
6.6
N.A.
13.3
6.6
80
80
N.A.
0
20
13.3
13.3
P-Site Similarity:
100
53.3
100
100
N.A.
100
20
N.A.
26.6
20
93.3
86.6
N.A.
20
40
46.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
23.9
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
35.7
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
20
0
0
40
0
0
0
0
7
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
14
14
0
0
0
0
14
0
0
14
7
0
7
60
% D
% Glu:
14
7
47
0
0
0
0
0
0
0
14
0
0
0
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
7
0
0
7
40
7
0
7
20
14
14
74
0
7
0
% G
% His:
0
7
0
7
0
0
0
7
0
0
0
0
0
0
0
% H
% Ile:
7
7
7
0
7
0
20
7
0
0
0
0
14
7
14
% I
% Lys:
0
0
0
14
0
60
0
0
14
14
0
0
0
14
7
% K
% Leu:
7
7
7
0
0
0
0
0
0
0
47
14
47
0
0
% L
% Met:
0
14
0
0
14
0
0
7
0
7
0
0
7
0
0
% M
% Asn:
0
0
0
0
0
0
7
0
14
0
14
0
0
7
0
% N
% Pro:
0
0
0
0
14
0
0
14
0
7
0
0
7
0
0
% P
% Gln:
0
0
0
0
7
0
0
0
7
0
0
0
0
47
0
% Q
% Arg:
14
40
0
0
0
14
0
0
7
0
0
0
0
0
14
% R
% Ser:
27
0
0
47
14
0
14
34
40
47
0
0
7
7
0
% S
% Thr:
27
0
0
0
7
7
7
0
0
0
0
0
7
7
0
% T
% Val:
0
7
0
7
0
14
14
14
0
14
0
0
14
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
20
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _